Michel M Ouellette Selected Research

Pancreatic Neoplasms (Pancreatic Cancer)

3/2024	PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.
1/2022	The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells.
12/2021	p53/FBXL20 axis negatively regulates the protein stability of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase.
1/2020	Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.
10/2019	PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells.
1/2018	Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.
10/2017	Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells.
8/2017	Biological determinants of radioresistance and their remediation in pancreatic cancer.
5/2017	Discovery and characterization of small molecule Rac1 inhibitors.
2/2016	CXCR2 signaling regulates KRAS(G¹²D)-induced autocrine growth of pancreatic cancer.

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Michel M Ouellette Research Topics

Disease

16	Pancreatic Neoplasms (Pancreatic Cancer) 03/2024 - 03/2007
15	Neoplasms (Cancer) 03/2022 - 03/2007
5	Adenocarcinoma 01/2022 - 08/2005
3	Carcinogenesis 01/2022 - 10/2019
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2022
1	Squamous Cell Carcinoma of Head and Neck 01/2022
1	Neoplastic Cell Transformation 03/2007
1	Metaplasia 08/2005

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2007
3	GTP Phosphohydrolases (GTPases)IBA 01/2020 - 11/2014
3	Telomerase (Telomerase Reverse Transcriptase)IBA 10/2017 - 07/2011
2	Messenger RNA (mRNA)IBA 01/2022 - 12/2021
2	Protein Isoforms (Isoforms)IBA 02/2016 - 03/2007
2	Tumor Viral Antigens (Large T Antigen)IBA 01/2016 - 03/2007
1	Small Interfering RNA (siRNA)IBA 03/2024
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Immunologic Factors (Immunomodulators)IBA 01/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2021
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 12/2021
1	HoloenzymesIBA 10/2019
1	Long-Acting Thyroid Stimulator (LATS)IBA 10/2019
1	Oncogene Proteins (Oncogene Protein)IBA 10/2019
1	SmokeIBA 01/2018
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 10/2017
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 05/2017
1	CXC ChemokinesIBA 02/2016
1	CateninsIBA 01/2016
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 01/2016
1	Deubiquitinating EnzymesIBA 08/2014
1	Peptide Hydrolases (Proteases)FDA Link 08/2014
1	imetelstatIBA 01/2014
1	Amyloid (Amyloid Fibrils)IBA 10/2012
1	GlycosaminoglycansIBA 10/2012
1	EpitopesIBA 03/2007
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 03/2007
1	NestinIBA 08/2005
1	Complementary DNA (cDNA)IBA 08/2005

Therapy/Procedure

5	Radiotherapy 03/2022 - 11/2014
2	Therapeutics 11/2014 - 07/2011